Puregon

Puregon (follitropin beta) is a fertility medication that contains recombinant follicle-stimulating hormone (rFSH). It is commonly used to stimulate egg production in women undergoing fertility treatments such as in vitro fertilization (IVF) or intrauterine insemination (IUI). In men, it can be used to boost sperm production in cases of hypogonadotropic hypogonadism (low sperm count due to hormonal issues).

How Puregon Helps with Infertility

For Women:

• Stimulates the growth of ovarian follicles (eggs)

• Used in ovulation induction for women with conditions like PCOS

• Supports controlled ovarian stimulation in IVF treatments

For Men:

• Stimulates sperm production in cases of hormonal imbalances

• Often combined with hCG (human chorionic gonadotropin) for better results

Possible Side Effects

• Ovarian Hyperstimulation Syndrome (OHSS) (bloating, pain, nausea)

• Increased risk of multiple pregnancies (twins or more)

• Injection site reactions (redness, swelling)

• Mood swings, headaches, fatigue

Who Should NOT Use Puregon?

• Women with primary ovarian failure (non-functioning ovaries)

• Those with unexplained vaginal bleeding

• Men or women with hormone-sensitive cancers

• Individuals with severe ovarian cysts (unrelated to PCOS)

Dosage & Administration

For Women (Ovulation Induction & IVF Stimulation)

• Dosage: Typically starts at 50-150 IU per day, depending on ovarian response.

• Administration:

  • Injected subcutaneously (under the skin), usually in the abdomen or thigh.

  • Given once daily for about 7-14 days.

  • Dosage may be adjusted based on follicle growth monitored via ultrasound.

• Trigger Injection: When follicles reach the right size, an hCG injection (like Ovitrelle) is given to trigger ovulation.

For Men (Sperm Production in Hypogonadotropic Hypogonadism)

• Dosage: Typically 150 IU three times per week.

• Administration:

  • Injected subcutaneously or intramuscularly.

  • Often used in combination with hCG to enhance sperm production.

• Treatment Duration: May take 3-6 months to see results.

Success Rates

• Success depends on age, ovarian reserve, and overall fertility health.

• Women under 35 using Puregon for IVF have about 50-60% success per cycle.

• For women over 40, success rates decline significantly.

• In men, sperm production improvement is seen in about 60-80% of cases, but it can take months.